In addition, spoiler-phobes out there should beware, as apparently this trailer gives away a lot of plot.  You've been duly warned of potential spoilers.

While there are plenty of big-name actors on which to successfully sell this movie, the scale demands an extended ensemble, and this trailer gives many of them a chance to shine, however briefly each appears.  Amongst the faultless actors on hand for the decimation of our species are John Hawkes, Bryan Cranston, Laurence Fishburne, Enrico Colantoni, Jennifer Ehle, Sanna Lathan, Elliott Gould, and Demetri Martin. 

The Informant! screenwriter Scott Z. Burns wrote the script, and he's currently collaborating with Steven Soderbergh on The Man from U.N.C.L.E.

The film looks intense and unnervingly plausible, with a vibe that feels like a proper apocalyptic zombie movie without the zombies to place it comfortingly in the realm of horror.  Basically, it looks grueling and all manner of jacked up.

Contagion will mortify audiences this fall, hitting theaters on September 9th.